Cardiac toxicity of 5-fluorouraci1 in rabbits

5-FU-induced cardiac toxicity - an underestimated problem in radiooncology?

BACKGROUND 5-Fluorouracil (5-FU) is an antimetabolite, which is frequently used as chemotherapeutic agent for combined chemoradiotherapy. The purpose of this study was to present the clinical course of three patients who developed severe cardiac toxicity by 5-FU and to give a review of the literature on the cardiotoxic potential of 5-FU. RESULTS Cardiotoxicity is a rare, but relevant side eff...

P 191 Corneal endothelial toxicity of liposome encapsulated 5-fluorouridine in rabbits

P"rpse: To investigate the clinical and histological toxicity of the exposure of the :rabbit cornea1 endothelium to anterior chamber injection of liposome-encapsulated 5-fluorouridine (LS-FUR) at concentrations of 1 mg/ml and 0.38 mg/ml and intravitreal injection of I.5FUR at 1 mg/ml. M*thOdS : A total of 12 New Zealand white rabbits were divided in three groups: A) Anterror chamber rnjectian o...

The distribution of the cardiac veins in the New Zealand White rabbits (Oryctolagus cuniculus)

In this investigation, 25 adult New Zealand White rabbits randomly selected from both sexes and studied.Coloured latex injection and corrosion cast methods were applied on the materials. This study was carried out to disclose the distribution of the cardiac veins of the New Zealand White rabbits. The veins that drain the heart were found to be the great cardiac vein, the middle cardiac vein, th...

Effects of Nigella sativa oil and ascorbic acid against oxytetracycline-induced hepato-renal toxicity in rabbits

Objective(s):  Oxytetracycline (OTC) is a broad spectrum antibiotic widely used for treatment of a wide range of infections. However, its improper human and animal use leads to toxic effects, including hepatonephrotoxicity. Our objective was to evaluate protective effects of Nigella sativa oil (NSO) and/or ascorbic acid (AA), against OTC-induced hepatonephrotoxicity in rabbits. Materials and Me...

Blood volume and molybdenum toxicity in rabbits.